§176.300 Slimicides
（a） Slimicides may be safely used in the manufacture of paper and paperboard that contact food, in accordance with the following prescribed conditions:
（1） Slimicides are used as antimicrobial agents to control slime in the manufacture of paper and paperboard.
（2） Subject to any prescribed limitations, slimicides are prepared from one or more of the slime-control substances named in paragraph （c） of this section to which may be added optional adjuvant substances as provided for under paragraph （d） of this section.
（3） Slimicides are added to the process water used in the production of paper or paperboard, and the quantity added shall not exceed the amount necessary to accomplish the intended technical effect.
（b） To insure safe usage, the label or labeling of slimicides shall bear adequate directions for use.
（c） Slime-control substances permitted for use in the preparation of slimicides include substances subject to prior sanction or approval for such use and the following:
| List of substances | Limitations |
| Acrolein | |
| Alkenyl (C16-C18) dimethylethyl-ammonium bromide | |
| n-Alkyl (C12-C18) dimethyl benzyl ammonium chloride | |
| 1,2-Benzisothiazolin-3-one | At a level of 0.06 pound per ton of dry weight fiber. |
| Bis(1,4-bromoacetoxy)-2-butene | |
| 5,5-Bis(bromoacetoxymethyl) m-dioxane | |
| 2,6-Bis(dimethylaminomethyl) cyclohexanone | |
| 1,2-Bis(monobromoacetoxy) ethane [CA Reg. No. 3785-34-0] | At a maximum level of 0.10 pound per ton of dry weight fiber. |
| Bis(trichloromethyl)sulfone | |
| 4-Bromoacetoxymethyl-m-dioxolane | |
| 2-Bromo-4′-hydroxyacetophenone | |
| 2-Bromo-2-nitropropane-1,3-diol (CAS Reg. No. 52-51-7) | At a maximum level of 0.6 pound per ton of dry weight fiber. |
| β-Bromo-β-nitrostyrene | At a maximum level of 1 pound per ton of dry weight fiber. |
| Chloroethylenebisthiocyanate | |
| 5-Chloro-2 - methyl - 4 - isothiazolin-3-one calcium chloride and 2-methyl-4-isothiazolin-3-one calcium chloride mixture at a ratio of 3 parts to 1 part | At a level of 2.5 pounds per ton of dry weight fiber. |
| Chlorinated levulinic acids | |
| Chloromethyl butanethiolsulfonate | |
| Cupric nitrate | |
| n-Dialkyl (C12-C18) benzylmethylammonium chloride | |
| Code of Federal Regulations 236 | |
| 1,2-Dibromo-2,4-dicyanobutane (CAS Reg. No. 35691-65-7) | At a maximum level of 0.005% of dry weight fiber. |
| 2,2-Dibromo-3-nitrilopropionamide | At a maximum level of 0.1 lb/ton of dry weight fiber. |
| 2,3-Dibromopropionaldehyde | |
| 4,5-dichloro-1, 2-dithiol-3-one (CAS Reg. No. 1192-52-5) | For use only at levels not to exceed 10 milligrams per kilogram in the pulp slurry. |
| 1,3-Dihalo-5,5-dimethylhydantoin (where the dihalo (halogen) may be bromine and/or chlorine) that may contain no more than 20 weight percent 1,3-dihalo-5-ethyl-5-methylhydantoin (where the dihalo (halogen) may be bromine and/or chlorine). | At a maximum level of 1.0 kilogram (kg) per 1,000 kg of dry weight fiber. |
| 4-(Diiodomethylsulfonyl) toluene (CAS Reg. No. 20018-09-1). | At a maximum level of 0.2 pound per ton (100 grams/1,000 kilograms) of dry weight fiber. |
| 3,5-Dimethyl 1,3,5,2H-tetrahydrothiadiazine-2-thione | |
| Dipotassium and disodium ethylenebis(dithiocarba-mate) | |
| Disodium cyanodithioimidocarbonate | |
| n-Dodecylguanidine hydrochloride | At a maximum level of 0.20 pound per ton of dry weight fiber. |
| Glutaraldehyde (CAS Reg. No. 111-30-8) | |
| 2-(p-hydroxyphenyl) glyoxylohydroximoyl chloride (CAS Registry No. 34911-46-1) | At a level of 0.02 pound per ton of dry weight fiber. |
| 2-Hydroxypropyl methanethiol sulfonate | |
| 2-Mercaptobenzothiazole | |
| Methylenebisbutanethiolsulfonate | |
| Methylenebisthiocyanate | |
| 2-Nitrobutyl bromoacetate [CA Reg. No. 32815-96-6] | At a maximum level of 0.15 pound per ton of dry weight fiber. |
| N-[α-(Nitroethyl)benzyl] ethylenediamine | |
| Potassium 2-mercaptobenzothiazole | |
| Potassium N-hydroxymethyl-N-methyldithiocarba-mate | |
| Potassium N-methyldithiocarbamate | |
| Potassium pentachlorophenate | |
| Potassium trichlorophenate | |
| Silver fluoride | Limit of addition to process water not to exceed 0.024 pound, calculated as silver fluoride, per ton of paper produced. |
| Silver nitrate | |
| Sodium dimethyldithiocarbamate | |
| Sodium 2-mercaptobenzothiazole | |
| Sodium pentachlorophenate | |
| Sodium trichlorophenate | |
| 1,3,6,8-Tetraazatricyclo[6.2.1.13,6] dodecane | |
| 3,3,4,4-Tetrachlorotetrahydrothiophene-1,1-dioxide | |
| Tetrakis(hydroxymethyl)phosphonium sulfate (CAS Reg. No. 55566-30-8) | Maximum use level of 84 mg/kg in the pulp slurry. The additive may also be added to water, which when introduced into the pulp slurry, results in a concentration in the pulp slurry not to exceed 84 mg/kg. |
| 2-(Thiocyanomethylthio) benzothiazole | |
| Vinylene bisthiocyanate |
（d） Adjuvant substances permitted to be used in the preparation of slimicides include substances generally recognized as safe for use in food, substances generally recognized as safe for use in paper and paperboard, substances permitted to be used in paper and paperboard by other regulations in this chapter, and the following:
Acetone.
Butlylene oxide.
Dibutyl phthalate.
Didecyl phthalate.
N,N-Dimethylformamide.
Dodecyl phthalate.
Ethanolamine.
Ethylene glycol.
Ethylenediamine.
N-methyl-2-pyrrolidone （CAS Reg. No. 872-50-4）.
a,a′-[Methylenebis[4-（1,1,3,3-tetra-methyl-butyl）-o-phenylene]] bis[omega-hydroxypoly （oxyethylene）] having 6-7.5 moles of ethylene oxide per hydroxyl group.
Monomethyl ethers of mono-, di-, and tri-propyl-ene glycol.
Nonylphenol reaction product with 9 to 12 molecules of ethylene oxide.
Octylphenol reaction product with 25 molecules of propylene oxide and 40 molecules of ethylene oxide.
[42 FR 14554, Mar. 15, 1977, as amended at 42 FR 41854, Aug. 19, 1977; 44 FR 75627, Dec. 21, 1979; 46 FR 36129, July 14, 1981; 49 FR 5748, Feb. 15, 1984; 51 FR 19059, May 27, 1986; 51 FR 43734, Dec. 4, 1986; 54 FR 18103, Apr. 27, 1989; 55 FR 31825, Aug. 6, 1990; 64 FR 46130, Aug. 24, 1999; 64 FR 69900, Dec. 15, 1999; 65 FR 40497, June 30, 2000; 65 FR 70790, Nov. 28, 2000; 69 FR 24512, May 4, 2004]
