● 鞘糖脂(GSLs)是动物中丰富和多样化的糖脂类 (也存在于真菌、植物和无脊椎动物中)。鞘糖脂上出现的聚糖会在生理和病理上起到非常重要的作用。识别和测量鞘糖脂的能力在发育神经生物学以及溶酶体贮积症中的研究是非常重要的-例如黑朦性痴呆和戈谢病等疾病。人们对作为免疫治疗可能的靶标-鞘糖脂的兴趣与日俱增。● 神经酰胺聚糖酶用于从鞘糖脂上释放聚糖使之能够表征。它用β-糖基链切开包括GM1，GM2和GM3在内的聚糖。然后使用LudgerTag标记技术标记上聚糖。● 我们有从水蛭中提纯的神经酰胺聚糖酶和提供与缓冲液一起的试剂盒以及GM1醣脂类基质。Product Information:Cat # LZ-CER-HM-KIT includes enzyme, buffer and GM1 glycolipid substrateLudger Products for Analysis of Complex Glycans of GSLs:Cat# LT-KAB-A2 or LT-KAB-VP24 Ludger Tag? 2-AB Labeling KitCat# LT-KAA-A2 Ludger 2-AA Labeling KitCat# LC-S-A6 LudgerClean S cartridgesCat# E-S001 Sialidase Alpha- (2-3,6,8,9)Cat# CN-NA2-20U NA2 Glycan Internal StandardCat# CAB-GHP-30 2-AB Glucose Homopolymer LadderCat# LS-N2-4.6 x 150 Ludger Sep? N2 High Resolution Amide HPLC ColumnCat# LS-N-BUFFX40 Ludger Sep? N Buffer 40X concentrate
Glycosphingolipids (GSLs) are the most abundant and diverse class of glycolipids in animals (and are also present in fungi, plants, and invertebrates). Glycans present on GSLs have important roles in physiology and pathology. The ability to identify and measure GSLs is important for research in developmental neurobiology as well as lysosomal storage diseases such as Tay-Sachs and Gaucher’s disease. There is also growing interest in GSLs as possible targets for immunotherapy. Ceramide glycanase is an enzyme used to release glycans from GSLs to enable their characterisation. It cleaves glycans including GM1, GM2 and GM3 by cleaving the β-glycosyl linkage. Glycans can then be labelled using LudgerTag labelling technology.We have purified ceramide glycanase from Hirudo medicinalis and offer this in a kit along with buffer and GM1 glycolipid substrate.
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