产品型号： 2mg
产品名称： IDE-1
产品报价：
产品特点：
IDE-1的详细资料：
IDE-1 was identified in a high throughput screen as an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells1. IDE-1 is able to generate Sox17+/FoxA2+ cells to an equal or greater efficiency than that of protein (i.e. Activin A or Nodal) inducers of definitive endoderm in mouse or human ES cell cultures1. It has an EC50 of 125.5 nM and functions in part via activation of TGF-beta² signaling, as evident by Smad2 phosphorylation1. Endoderm chemically induced by IDE-1 can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos1
Product Specification
M.Wt: 306.31
Formula:C15H18N2O5
Solubility:Soluble to 100 mM in DMSO
Purity:>98 %Storage:
CAS No:[1160927-48-9]
Borowiak, M., Maehr, R., Chen, S., Chen, A.E., Tang, W., Fox, J.L., Schreiber, S.L., Melton, D.A. (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4: 348-58
产品相关关键字：IDE-1，抑制剂，小分子，1160927-48-9
| 相关同类产品： |
| 2mgTGF-β RI Kinase Inhibitor II (RepSox) | 2mgLY294002 | 2mgIDE-1 | |
| 20mgValproic acid sodium salt | 2mgPS48 | 2mgPyrintegrin | |
| 2mgLDN-193189 | 2mgY27632 | 2mgPTC124 | |
| 5mgRG108 | 5mgXAV939 | 2mgPD0325901 | |
| 2mgCHIR99021 | |||
产品型号： 5mg
产品名称： RG108
产品报价：
产品特点：
RG108的详细资料：
Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site.
Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.
Enhances the efficiency of induced pluripotent stem cell (iPS) generation 1
Product Specification
M.Wt: 334.33
Formula: C19H14N2O4
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity: >99 %
Storage: Store at RT
CAS No: [48208-26-0]
Shi Y, Desponts C, Do JT, et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell. 2008;3:568-574
产品相关关键字：RG108，抑制剂，小分子，48208-26-0
| 相关同类产品： |
| 2mgTGF-β RI Kinase Inhibitor II (RepSox) | 2mgLY294002 | 2mgIDE-1 | |
| 20mgValproic acid sodium salt | 2mgPS48 | 2mgPyrintegrin | |
| 2mgLDN-193189 | 2mgY27632 | 2mgPTC124 | |
| 5mgRG108 | 5mgXAV939 | 2mgPD0325901 | |
| 2mgCHIR99021 | |||
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