2020年5月20日，欧盟食品安全局发布关于一种磷脂酶A1（phospholipase A1）安全性的评估结果。
据了解，这种食品酶是由Novozymes A/S公司用转基因黑曲霉（Aspergillus niger）菌株NZYM ‐FP生产的。这种食品酶旨在用于油脂脱胶。经过评估，专家小组得出结论，这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下：
The food enzyme phospholipase A1 （phosphatidycholine 1‐acylhydrolase EC 3.1.1.32） is produced with the genetically modified Aspergillus niger strain NZYM ‐FP by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA . The phospholipase A1 food enzyme is intended to be used for degumming of fats and oils. Since residual amounts of Total Organic Solids （TOS ） are removed by the purification steps applied during degumming, dietary exposure estimation was not considered necessary. Genotoxicity tests did not raise safety concerns. The repeated dose 90‐day oral toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no‐observed‐adverse‐effect level （NOAEL ） of 1,356 mg TOS /kg body weight （bw） per day, the highest dose tested. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions upon dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided and the removal of TOS during the degumming of fats and oils, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
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日期：2020-05-21
