2023年6月9日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组就一种β-甘露聚糖酶（β-mannanase）作为所有育肥家禽饲料添加剂的安全性和有效性发表科学意见。
据了解，这种β-甘露聚糖酶由黑曲霉 CBS 120604产生。经过评估，专家小组认为在建议的使用条件下该添加剂对目标物种、消费者和环境是安全的。该添加剂在30 U/kg饲料水平下对育肥家禽是有效的。部分原文报道如下：
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of a product containing β-mannanase produced by a non-genetically modified strain of Aspergillus niger (CBS 120604). The commercial name is Nutrixtend Optim and it is intended to be used as a zootechnical feed additive for all poultry for fattening. based on a tolerance trial in chickens for fattening and the no observed adverse effect level identified in a subchronic oral toxicity study in rats, the additive was considered safe for all poultry for fattening. The Panel concluded that the use of the product as a feed additive does not give rise to concerns for consumers and the environment. The additive is considered an irritant to skin and eyes and a dermal sensitiser. Due to the proteinaceous nature of the active substance, it is also considered a respiratory sensitiser. The Panel concludes that the additive has the potential to be efficacious as a zootechnical additive at the level of inclusion in feed of chickens for fattening of 30 U β-mannanase/kg complete feed. This conclusion was extrapolated to all poultry for fattening.
