2023年2月24日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组就一种β-甘露聚糖酶（endo-1,4-β-d-mannanase）作为育肥鸡、育肥火鸡、饲养用于产蛋的鸡、饲养用于繁殖的火鸡、饲养用于产蛋的小型家禽物种、育肥猪、断奶仔猪和小型猪种饲料添加剂的安全性和有效性发表科学意见。
据了解，这种β-甘露聚糖酶由Paenibacillus lentus DSM 33618产生。经过评估，专家小组认为在建议的使用条件下该添加剂对目标物种、消费者和环境是安全的。该添加剂在32，000 U/kg饲料水平下对育肥鸡、饲养用于产蛋的鸡、饲养用于产蛋的小型家禽物种、育肥猪和小型猪种是有效的，在48，000 U/kg饲料水平下对育肥火鸡、饲养用于繁殖的火鸡和断奶仔猪有效。部分原文报道如下：
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of endo-1,4-β-d-mannanase (Hemicell® HT/HT-L) produced by a genetically-modified strain of Paenibacillus lentus (DSM 33618) as a zootechnical feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, minor poultry species to point of lay, pigs for fattening, piglets (weaned) and minor porcine species. The production strain was obtained from a Paenibacillus lentus recipient strain that has been evaluated previously by EFSA and considered to be safe. The genetic modification does not raise safety concerns and there were no antibiotic resistance genes from the genetic modification in the production strain. Viable cells and the DNA of the production strain were not found in the intermediate product used to formulate the additive. Hemicell® HT/HT-L produced by Paenibacillus lentus DSM 33618 is considered safe for the above-mentioned target species at the intended conditions of use. The use of Hemicell® HT/HT-L as a feed additive raises no concerns for the consumer or for the environment. Hemicell® HT/HT-L is not irritant to the skin and eyes but is regarded as a dermal sensitiser and a potential respiratory sensitiser. The additive has a potential to be efficacious at 32,000 U/kg in chickens for fattening, chickens reared for laying, minor poultry species for fattening or reared for laying/breeding, pigs for fattening and minor porcine species, and at 48,000 U/kg in turkeys for fattening, turkeys reared for breeding and weaned piglets.
